Restraint of Acetaminophen-Induced Liver Injury with Butylated Hydroxyanisole and Butylated Hydroxytoluene, and Its Effects on Hepatic Heat Shock Protein 25 and 70i
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چکیده
منابع مشابه
Hepatoprotective effect of food preservatives (butylated hydroxyanisole, butylated hydroxytoluene) on carbon tetrachloride-induced hepatotoxicity in rat
Carbon tetrachloride (CCl4), a hepatotoxic agent is widely used to study the toxic mechanisms in experimental animals. This study was carried out to establish the hepatoprotective measures of food preservative antioxidants butylated hydroxyanisole and butylated hydroxytolune (BHA, BHT) when mixed with food towards carbon tetrachloride (CCl4) intoxication (230 mg/ kg b wt/rat/day) in rat. Bioche...
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The modifying effects of antioxidants were examined in a carcinogenesis system after \, V-ililnilvlniinisamiiic treatment. Male F344 rats were given 0.05% V, Vdilnilylnhrosarnmiin their drinking water for 4 wk and then treated with basal diet containing 2% butylated hydroxyanisole (BHA), 1% butylated hydroxytoluene (BHT) with 7 ppm vitamin K, 0.8% ethoxyquin, 5% sodium L-ascorbate, 57. sodium e...
متن کاملIntake of butylated hydroxyanisole and butylated hydroxytoluene and stomach cancer risk: results from analyses in the Netherlands Cohort Study.
Both carcinogenic and anticarcinogenic properties have been reported for the synthetic antioxidants butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT). The association between dietary intake of BHA and BHT and stomach cancer risk was investigated in the Netherlands Cohort Study (NLCS) that started in 1986 among 120,852 men and women aged 55 to 69 years. A semi-quantitative food f...
متن کاملEffects of butylated hydroxyanisole on acetaminophen hepatotoxicity and glucuronidation in vivo.
The present study examined the effects of butylated hydroxyanisole (BHA) on acetaminophen-induced hepatotoxicity and metabolism in vivo with emphasis on possible changes in the glucuronidation pathway. Female Swiss-Webster mice received BHA in the diet (1% w/w) for 12 days (600 to 800 mg/kg/day). BHA prevented acetaminophen hepatotoxicity (600 mg/kg, ip), based on serum alanine and aspartate am...
متن کاملAntioxidant Properties of Thymol and Butylated Hydroxytoluene in Carbon Tetrachloride – Induced Mice Liver Injury
Thymol and Butylated hydroxytoluene (BHT) were tested for their ability to inhibit carbon tetrachloride (CCl4)-induced lipid peroxidation in mice liver. To achieve this purpose, four groups of mice were tested, GP I: Animals served as normal control, GP II: Animals injected i.p. with a single dose of CCl4 (0.5 ml/kg B.W), GP III and IV: Animals pretreated by oral administration of thymol or BHT...
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ژورنال
عنوان ژورنال: Journal of Oleo Science
سال: 2005
ISSN: 1345-8957,1347-3352
DOI: 10.5650/jos.54.273